Cost Effectiveness of Prophylactic Mastectomy and Autologous Flap Reconstruction in BRCA1/2 – Positive Patients

Plastic and Reconstructive Surgery, 2025

This analysis evaluates the long-term cost-effectiveness of prophylactic mastectomy with autologous reconstruction for individuals with BRCA1/2 mutations, examining how preventive surgery compares with ongoing cancer surveillance and treatment.

“Prophylactic mastectomy with autologous reconstruction performed at ages 30, 35 or 40 years, was found to be a cost-effective alternative to breast cancer surveillance and disease treatment in women with BRCA1/2 mutations.”

Read the study here.